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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
06/07/2017 |
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Data da última atualização: |
27/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ORTEGA, M. S.; WOHLGEMUTH, S.; TRIBULO, P.; SIQUEIRA, L. G. B.; NULL, D. J.; COLE, J. B.; SILVA, M. V. G. B.; HANSEN, P. J. |
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Afiliação: |
M. Sofia Ortega, University of Florida; Stephanie Wohlgemuth, University of Florida; Paula Tribulo, University of Florida; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; Daniel J. Null, United States Department of Agriculture; John B. Cole, United States Department of Agriculture; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; Peter J. Hansen, University of Florida. |
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Título: |
A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Biology of Reproduction, v. 96, n. 3, p. 652-663, 2017. |
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Idioma: |
Inglês |
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Conteúdo: |
A single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function. The mutation in COQ9 modifies predicted tertiary protein structure and affected mitochondrial respiration of peripheral blood mononuclear cells. The A allele was associated with low resting oxygen consumption and high electron transport system capacity. Phenotypic measurements for fertility were evaluated for up to five lactations in a population of 2273 Holstein cows. There were additive effects of the mutation (P < 0.05) in favor of the A allele for pregnancy rate, interval from calving to conception, and services per conception. There was no association of genotype with milk production or body weight changes postpartum. The mutation in COQ9 affected ovarian function; the A allele was associated with increased mitochondrial DNA copy number in oocytes, and there were overdominance effects for COQ9 expression in oocytes, follicle number, and antimullerian hormone concentrations. Overall, results show how a gene involved in mitochondrial function is associated with overall fertility, possibly in part by affecting oocyte quality. MenosA single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function. The mutation in COQ9 modifies predicted tertiary protein structure and affected mitochondrial respiration of peripheral blood mononuclear cells. The A allele was associated with low resting oxygen consumption and high electron transport system capacity. Phenotypic measurements for fertility were evaluated for up to five lactations in a population of 2273 Holstein cows. There were additive effects of the mutation (P < 0.05) in favor of the A allele for pregnancy rate, interval from calving to conception, and services per conception. There was no association of genotype with milk production or body weight changes postpartum. The mutation in COQ9 affected ovarian function; the A allele was associated with increased mitochondrial DNA copy number in oocytes, and there were overdominance effects for COQ9 expression in oocytes, follicle number, and antimullerian hormone concentrations. Overall, results show how a gene involved in mitochondrial function is associat... Mostrar Tudo |
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Palavras-Chave: |
COQ9; Oocyte. |
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Thesaurus Nal: |
cattle; genetic variation; mitochondria. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02335naa a2200265 a 4500
001 2072163
005 2023-01-27
008 2017 bl uuuu u00u1 u #d
100 1 $aORTEGA, M. S.
245 $aA single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows.$h[electronic resource]
260 $c2017
520 $aA single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function. The mutation in COQ9 modifies predicted tertiary protein structure and affected mitochondrial respiration of peripheral blood mononuclear cells. The A allele was associated with low resting oxygen consumption and high electron transport system capacity. Phenotypic measurements for fertility were evaluated for up to five lactations in a population of 2273 Holstein cows. There were additive effects of the mutation (P < 0.05) in favor of the A allele for pregnancy rate, interval from calving to conception, and services per conception. There was no association of genotype with milk production or body weight changes postpartum. The mutation in COQ9 affected ovarian function; the A allele was associated with increased mitochondrial DNA copy number in oocytes, and there were overdominance effects for COQ9 expression in oocytes, follicle number, and antimullerian hormone concentrations. Overall, results show how a gene involved in mitochondrial function is associated with overall fertility, possibly in part by affecting oocyte quality.
650 $acattle
650 $agenetic variation
650 $amitochondria
653 $aCOQ9
653 $aOocyte
700 1 $aWOHLGEMUTH, S.
700 1 $aTRIBULO, P.
700 1 $aSIQUEIRA, L. G. B.
700 1 $aNULL, D. J.
700 1 $aCOLE, J. B.
700 1 $aSILVA, M. V. G. B.
700 1 $aHANSEN, P. J.
773 $tBiology of Reproduction$gv. 96, n. 3, p. 652-663, 2017.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Biblioteca(s): |
Embrapa Instrumentação; Embrapa Milho e Sorgo. |
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Data corrente: |
13/02/2017 |
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Data da última atualização: |
20/03/2017 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
RIBEIRO, P. E. de A.; BARROS, L. C. de; RODRIGUES, L. S.; MINGOTE, D. A.; MARMO, C. R. |
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Afiliação: |
PAULO EDUARDO DE AQUINO RIBEIRO, CNPMS; LUCIANO CORDOVAL DE BARROS, CNPMS; Lorena Santos Rodrigues, Tecnóloga em Gestão Ambiental; Diego Assis Mingote, Tecnólogo em Gestão Ambiental; CARLOS RENATO MARMO, CNPDIA. |
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Título: |
Disseminação de tecnologias sociais e percepção da população rural sobre a implantação de fossas sépticas biodigestoras: estudo de caso. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
In: LANDAU, E. C.; MOURA, L. (Ed.). Variação geográfica do saneamento básico no Brasil em 2010: domicílios urbanos e rurais. Brasília, DF: Embrapa, 2016. cap. 10, p. 273-288. |
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ISBN: |
978-85-7035-672-7 |
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Idioma: |
Português |
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Conteúdo: |
O desenvolvimento, o aperfeiçoamento e a disseminação de tecnologias sociais simples e de baixo custo de implementação são fundamentais para garantir à população rural uma convivência mais digna com a escassez de água (CONTI; SCHOEDER, 2013). Nesse contexto, o papel dos agricultores familiares não deve ser de recebedor passivo das tecnologias prontas, mas de protagonista na mobilização e apropriação dessas tecnologias nas comunidades, visto que são eles quem melhor conhecem sua realidade e como seu ambiente se comporta. |
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Palavras-Chave: |
Armazenamento de água. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/157837/1/GeoSaneamento-Cap10.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/232918/1/2017-Disseminacao-de-Tecnologias-Sociais-e.pdf
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Marc: |
LEADER 01320naa a2200193 a 4500
001 2063693
005 2017-03-20
008 2016 bl uuuu u00u1 u #d
020 $a978-85-7035-672-7
100 1 $aRIBEIRO, P. E. de A.
245 $aDisseminação de tecnologias sociais e percepção da população rural sobre a implantação de fossas sépticas biodigestoras$bestudo de caso.$h[electronic resource]
260 $c2016
520 $aO desenvolvimento, o aperfeiçoamento e a disseminação de tecnologias sociais simples e de baixo custo de implementação são fundamentais para garantir à população rural uma convivência mais digna com a escassez de água (CONTI; SCHOEDER, 2013). Nesse contexto, o papel dos agricultores familiares não deve ser de recebedor passivo das tecnologias prontas, mas de protagonista na mobilização e apropriação dessas tecnologias nas comunidades, visto que são eles quem melhor conhecem sua realidade e como seu ambiente se comporta.
653 $aArmazenamento de água
700 1 $aBARROS, L. C. de
700 1 $aRODRIGUES, L. S.
700 1 $aMINGOTE, D. A.
700 1 $aMARMO, C. R.
773 $tIn: LANDAU, E. C.; MOURA, L. (Ed.). Variação geográfica do saneamento básico no Brasil em 2010: domicílios urbanos e rurais. Brasília, DF: Embrapa, 2016. cap. 10, p. 273-288.
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Embrapa Milho e Sorgo (CNPMS) |
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